A Network Biology Approach to Discover the Molecular Biomarker Associated with Hepatocellular Carcinoma

Table 1

Top five ranked survival related subnetworks.

Network rank	Component genes	Univariate Cox 𝑃 value	Adjusted multivariable Cox 𝑃 values
1	CCR7	3.10𝐸−01	8.69𝐸−06
	XCL1	5.10𝐸−03
	VCAN	2.00𝐸−02
	CCL21	4.80𝐸−03
	CCL19	4.80𝐸−03
	FBLN2	5.00𝐸−04
2	HIST1H2BJ	2.60𝐸−01	1.02𝐸−05
	LOX	1.70𝐸−01
	DPT	3.00𝐸−02
	BAT3	5.30𝐸−02
	ELN	4.70𝐸−02
	FBLN2	5.00𝐸−04
	ASS1	5.10𝐸−02
3	PPIL2	2.30𝐸−01	1.61𝐸−05
	BSG	1.90𝐸−01
	MMP1	2.00𝐸−04
	SLC16A1	6.00𝐸−02
	TIMP1	1.50𝐸−01
	CAV1	1.30𝐸−01
	TNFRSF1B	2.70𝐸−03
	CSNK2A2	3.50𝐸−02
	GNAI2	3.20𝐸−02
	MAPK3	3.30𝐸−02
4	CCR6	4.50𝐸−01	4.59𝐸−05
	CCL20	2.10𝐸−01
	VCAN	2.00𝐸−02
	FBLN2	4.00𝐸−04
	CCL21	4.80𝐸−03
	XCL1	5.10𝐸−03
5	ACAA2	2.60𝐸−02	9.65𝐸−05
	SCP2	1.30𝐸−01
	ACOX1	8.20𝐸−01
	CAV1	1.30𝐸−01
	TNFRSF1B	2.70𝐸−03
	CSNK2A2	3.50𝐸−02
	GNAI2	3.20𝐸−02
	MAPK3	3.30𝐸−02