Administration of the Resveratrol Analogues Isorhapontigenin and Heyneanol-A Protects Mice Hematopoietic Cells against Irradiation Injuries
Figure 4
REV, ISOR, and HEY-A reduce IR-induced suppression of posttransplantation long-term engraftment of HSCs. Donor BMMNC received treatment with control, REV, ISOR, or HEY-A (1 μM) before being treated with IR (2 Gy); the BMMNC were then mixed with competitive cells. Cells were transplanted into receptor mice as described in the paper text, and donor cell engraftment was analyzed 2 months after transplantation. The data are expressed as means ± SE of the percentage of donor-derived cells in the peripheral blood. (a) donor-derived leukocytes (CD45.1 + CD45.2 − cells), (b) donor-derived B cells (CD45.1 + CD45.2 − B220 + cells), (c) donor-derived T cells (CD45.1 + CD45.2 − CD3 + cells), and (d) donor-derived myeloid cells (CD45.1 + CD45.2 − CD11b + and/or Gr-1 + granulocyte-monocyte-macrophage). versus control; versus vehicle, ( recipient mice/group). REV: resveratrol; ISOR: isorhapontigenin; HEY-A: heyneanol-A; IR: ionizing radiation; HSC: hematopoietic stem cell; BMMNC: bone marrow mononuclear cells.
