An ANOCEF Genomic and Transcriptomic Microarray Study of the Response to Irinotecan and Bevacizumab in Recurrent Glioblastomas

Figure 2

Unsupervised hierarchical clustering of the 23 GBMs. The heatmap was constructed using the 2365 probesets (quantile 0.95), with the greatest robust coefficient of variation between the tumor samples. The samples and genes were clustered using Ward’s linkage and Pearson’s correlation coefficient. For each probe set, the lowest and highest intensity values are displayed in blue and red, respectively. Response: black = responder, white = nonresponder. Verhaak = class according to Verhaak et al.’s classification [7]: neural = green, classical = red, mesenchymal = blue, and proneural = orange.