An ANOCEF Genomic and Transcriptomic Microarray Study of the Response to Irinotecan and Bevacizumab in Recurrent Glioblastomas

Table 2

Characteristics of the 33 patients from the Salpêtrière database for whom the impact of EGFR amplification and CDKN2A locus homozygous deletion was assessed.

Characteristics of the 33 patients of the independent dataset
Number of patients	33
Median age (years) at diagnosis (range)	59 (25–81)
Initial treatment (%)	RTCT (100%)
Median delay (months) between diagnosis and bev./iri. onset (range)	15 (3.5–60)
Recurrence number at bev./iri. onset
First	31
Second/third	1/1
Response according to RANO
Complete	4
Partial	11
Stable	7
Progression	7
Not assessable	3
EGFR amplification	13
CDKN2A homozygous deletion	12
Median PFS after bev./iri. onset (months)	5.5
Median OS after bev./iri. onset (months)	9.7
Median OS since diagnosis (months)	29

RTCT: temozolomide radiochemotherapy; bev./iri.: bevacizumab/irinotecan chemotherapy; KPS: Karnofsky performance status; PFS: progression-free survival; OS: overall survival; ns, nonsignificant.