Follicular Fluid Oocyte/Cumulus-Free DNA Concentrations as a Potential Biomolecular Marker of Embryo Quality and IVF Outcome
Table 1
Characteristics (mean ± SEM) of women according to the number of oocyte/cumulus complexes (CoCs) collected during ovum pickup.
CoCs
≥2
=1
P value
Number of cases
63
21
Age of woman (y)
35.8 ± 0.6
37.47 ± 1.1
NS
BMI of woman (kg/m2)
25.93 ± 0.6
25.54 ± 1.2
NS
Basal FSH (mIU/mL)1
7.67 ± 0.4
7.51 ± 0.7
NS
Infertility duration (y)
3.46 ± 0.2
3.44 ± 0.5
NS
Basal LH (mIU/mL)1
4.63 ± 0.3
4.61 ± 0.6
NS
Estradiol (pg/mL)2
1722.3 ± 128.18
1735 ± 262.3
NS
CoCs
7.23 ± 0.5
1
<0.05
FR (%)
67.37 ± 2.7
76.19 ± 5.5
NS
CR (%)
82.25 ± 3.7
80.95 ± 8.7
NS
CES
32.07 ± 2.9
6.91 ± 0.9
<0.05
MSEQ
8.48 ± 0.4
6.91 ± 0.9
NS
MSET
9.69 ± 0.4
6.91 ± 0.9
<0.05
Follicular fluid oocytes/cumulus-free DNA (ng/mL)
1165.65 ± 142.7
2077.31 ± 629.9
<0.05
Smoking status (packs-year history)
0.21 ± 0.0
0.14 ± 0.0
NS
Alcohol status (alcohol units)
0.61 ± 0.1
0.33 ± 0.2
NS
Positive hCG (%)
28.6%
14.3%
NS
Clinical pregnancy (%)
23.8%
14.3%
NS
FSH and LH values on day 2 of the menstrual cycle.
2Estradiol values on the day of human chorionic gonadotropin (hCG). y, years; BMI, body mass index; FR, fertilization rate; CR, cleavage rate; CES, cumulative embryo score; MSEQ, mean score of embryo quality; MSET, mean score of embryo transfer.
