Novel Hypoxanthine Guanine Phosphoribosyltransferase Gene Mutations in Saudi Arabian Hyperuricemia Patients

Table 3

Predicting the effect of the two mutations (K103M and V160G) on HPRT protein function using SNAP and PoPMuSiC.

Mutations	SNAP			PoPMuSiC
nsSNP	Prediction	Reliability index	Expected accuracy	ΔΔ𝐺 (kcal/mol)	Prediction
K103M	Nonneutral	2	70%	−0.04	Stabilizing
V160G	Nonneutral	1	63%	3.23	Destabilizing