Common Polymorphism in the LRP5 Gene May Increase the Risk of Bone Fracture and Osteoporosis

Table 1

Baseline characteristics and methodological quality of all included studies.

First author	Year	Ethnicity	Disease	Sample size		Gender (M/F)		Age (years)		Genotyping methods	NOS score
				Case	Control	Case	Control	Case	Control
Xuan [33]	2014	Asians	OP	90	78	0/90	0/78	60.0 ± 3.0	60.5 ± 2.7	PCR-RFLP	8
				90	96	0/90	0/78	60.0 ± 3.0	60.4 ± 3.2	PCR-RFLP
Falcón-Ramírez [22]	2013	Caucasians	OP	100	217	0/100	0/217	64.7 ± 10.5	57.4 ± 12.0	TaqMan assay	8
Liu [34]	2010	Asians	Fracture	284	728	0/284	0/728	60.1 ± 10.5	54.9 ± 11.2	TaqMan assay	8
Furuya [16]	2009	Asians	Fracture	119	441	0/95	0/441	—	—	TaqMan assay	8
Hartikka [35]	2005	Caucasians	OP	20	88	11/9	—	10.0 (4.0~16.0)	—	TaqMan assay	7
Ferrari [31]	2005	Caucasians	OP	78	86	78/0	86/0	50.7 ± 9.9	49.8 ± 16.1	Pyrosequencing	8
Mizuguchi [32]	2004	Asians	OP	126	131	0/126	0/131	—	—	TaqMan assay	7

M: male, F: female, PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism, NOS: Newcastle-Ottawa Scale.