The Relationship between Interleukin-18 Polymorphisms and Allergic Disease: A Meta-Analysis

Table 2

Meta-analysis of IL-18 −607C/A and −137G/C polymorphisms with risk of allergic disease.

	Allele model		Dominant model		Recessive model		Homozygous comparison		Heterozygous comparison
	OR [95% CI]	𝑃	OR [95% CI]	𝑃	OR [95% CI]	𝑃	OR [95% CI]	𝑃	OR [95% CI]	𝑃
IL-18  −607C/A	A allele versus C allele		AA + AC versus CC		AA versus CC + AC		AA versus CC		AC versus CC
Overall	1.03 [0.91–1.15]	0.67	1.02 [0.85–1.22]	0.86	1.07 [0.88–1.28]	0.51	1.01 [0.77–1.33]	0.94	1.00 [0.83–1.21]	0.98
Type of disease
AA	0.98 [0.89–1.08]	0.72	0.87 [0.74–1.03]	0.10	1.08 [0.82–1.43]	0.58	0.88 [0.61–1.27]	0.48	0.82 [0.69–0.98]	0.03
AD	1.15 [0.81–1.64]	0.44	1.39 [0.80–2.41]	0.24	1.01 [0.55–1.87]	0.98	1.27 [0.61–2.65]	0.53	1.42 [0.79–2.56]	0.24
AR	1.05 [0.88–1.24]	0.60	1.36 [0.55–3.34]	0.51	1.00 [0.73–1.36]	0.98	1.21 [0.84–1.75]	0.30	1.49 [0.47–4.78]	0.50
Other types	1.02 [0.74–1.43]	0.89	1.02 [0.66–1.60]	0.92	1.09 [0.67–1.78]	0.72	1.09 [0.55–2.18]	0.80	1.03 [0.70–1.51]	0.88
Ethnicity
Asian	1.04 [0.88–1.24]	0.61	1.10 [0.82–1.46]	0.53	1.02 [0.80–1.31]	0.85	0.96 [0.64–1.45]	0.86	1.12 [0.82–1.52]	0.47
Caucasian	0.97 [0.88–1.08]	0.57	0.90 [0.77–1.04]	0.15	1.14 [0.83–1.56]	0.42	1.02 [0.82–1.27]	0.86	0.86 [0.73–1.01]	0.06
Source of control
PB	0.93 [0.86–1.01]	0.11	0.86 [0.76–0.98]	0.03	0.97 [0.85–1.11]	0.69	0.80 [0.68–0.95]	0.009	0.85 [0.74–0.98]	0.03
HB	1.27 [1.03–1.57]	0.03	1.36 [0.94–1.96]	0.10	1.46 [0.97–2.21]	0.07	1.75 [1.14–2.68]	0.01	1.27 [0.84–1.94]	0.26
IL-18  −137G/C	C allele versus G allele		CC + CG versus GG		CC versus CG + GG		CC versus GG		CG versus GG
Overall	0.93 [0.80–1.07]	0.31	0.97 [0.82–1.14]	0.70	0.77 [0.58–1.02]	0.07	0.76 [0.55–1.04]	0.08	1.02 [0.88–1.18]	0.78
Type of disease
AA	0.94 [0.86–1.03]	0.21	0.97 [0.87–1.08]	0.63	0.80 [0.63–1.02]	0.07	0.80 [0.63–1.02]	0.07	1.00 [0.90–1.12]	0.95
AD	0.66 [0.30–1.46]	0.30	0.70 [0.29–1.71]	0.44	0.30 [0.15–0.60]	<0.001	0.26 [0.12–0.53]	<0.001	0.84 [0.38–1.82]	0.65
AR	0.93 [0.75–1.16]	0.51	0.94 [0.71–1.25]	0.68	0.81 [0.48–1.37]	0.43	0.80 [0.47–1.37]	0.42	0.97 [0.73–1.30]	0.85
Other types	0.96 [0.61–1.53]	0.87	1.00 [0.60–1.66]	0.99	0.71 [0.47–1.09]	0.12	0.70 [0.46–1.08]	0.11	1.05 [0.66–1.68]	0.84
Ethnicity
Asian	1.05 [0.85–1.30]	0.64	1.12 [0.89–1.39]	0.34	0.78 [0.54–1.12]	0.18	0.81 [0.56–1.16]	0.25	1.15 [0.93–1.43]	0.20
Caucasian	0.80 [0.66–0.98]	0.03	0.83 [0.68–1.02]	0.08	0.71 [0.49–1.02]	0.06	0.66 [0.43–1.00]	0.05	0.93 [0.83–1.05]	0.24
Source of control
PB	0.87 [0.73–1.05]	0.14	0.91 [0.76–1.10]	0.35	0.76 [0.51–1.11]	0.15	0.73 [0.48–1.12]	0.15	0.98 [0.87–1.10]	0.72
HB	1.04 [0.77–1.39]	0.81	1.09 [0.79–1.51]	0.60	0.72 [0.54–0.96]	0.03	0.72 [0.53–0.97]	0.03	1.14 [0.85–1.54]	0.38

AA, allergic asthma; AD, allergic dermatitis; AR, allergic rhinitis; PB, population-based control; HB, hospital-based control.