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BioMed Research International
Volume 2014 (2014), Article ID 290863, 6 pages
http://dx.doi.org/10.1155/2014/290863
Research Article

Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population

1Division of Nephrology, Department of Medicine, Kaohsiung Medical University Hospital/Kaohsiung Medical University, Kaohsiung 807, Taiwan
2Department of Pharmacy, Taipei Medical University Hospital, Taipei 110, Taiwan
3Department of Clinical Pharmacy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
4Clinical Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan
5Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
6Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan
7Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
8Department of Medical Genetics, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
9Department of Internal Medicine, School of Medicine, Taipei Medical University, Taipei 110, Taiwan
10Department of Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
11Faculty of Renal Care, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan

Received 13 December 2013; Accepted 6 February 2014; Published 17 March 2014

Academic Editor: Wei Chiao Chang

Copyright © 2014 Daw-Yang Hwang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Taiwan has very high incidence and prevalence of chronic kidney disease (CKD), which easily progresses to end-stage renal disease (ESRD). The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channels which are involved in the regulation of immune system. Hence, we conducted a case-control study to determine whether the genetic polymorphisms of ORAI1 gene is a susceptibility factor to CKD and its clinical features in a Taiwanese population. Five hundred seventy-nine CKD patients from a hospital-based CKD care program were included in the study. Five tagging single nucleotide polymorphisms (tSNPs) of ORAI1 were selected from the genotyping data of the Han Chinese population from the HapMap project. Among these polymorphisms, rs12313273 was found to be significantly associated with elevated serum calcium levels, which has been linked to increased risk of death in CKD patients. To have a better management of serum calcium, we suggest that ORAI1 polymorphisms might be used as a potential biomarker for initiating non-calcium-based phosphate binder in CKD patients in the future.