Dual Binding Site and Selective Acetylcholinesterase Inhibitors Derived from Integrated Pharmacophore Models and Sequential Virtual Screening

<table>Pharmacophore model of BChE inhibitors generated by HYPOREFINE. (a) The best HYPOREFINE model Hypo1_B. (b) Hypo1_B mapping with one of the most active compound<b> 17</b> (IC<sub>50</sub> = 3.3 nM). Pharmacophore features are color-coded with blue for hydrophobic feature, orange for ring aromatic feature, green for hydrogen-bond acceptor, and grey for excluded volumes.</table>

BioMed Research International

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Figure 4: Dual Binding Site and Selective Acetylcholinesterase Inhibitors Derived from Integrated Pharmacophore Models and Sequential Virtual Screening 

Figure 4 | Dual Binding Site and Selective Acetylcholinesterase Inhibitors Derived from Integrated Pharmacophore Models and Sequential Virtual Screening 