Dual Binding Site and Selective Acetylcholinesterase Inhibitors Derived from Integrated Pharmacophore Models and Sequential Virtual Screening

Table 5

Results of Fischer’s randomization test for Hypo1_A at 95% using Cat-Scramble implemented in DS2.5 software.

Validation number	Total cost	Null cost	Cost diff.	Correlation (r)
Hypo1_A	121.22	309.61	188.38	0.9588
Results for scrambled
Trial 1	247.12	309.61	62.49	0.6452
Trial 2	216.08	309.61	93.53	0.8326
Trial 3	208.01	309.61	101.59	0.8324
Trial 4	223.79	309.61	76.82	0.7378
Trial 5	232.78	309.61	76.82	0.7090
Trial 6	257.60	309.61	52.01	0.6158
Trial 7	205.35	309.61	104.26	0.7857
Trial 8	207.48	309.61	102.13	0.7614
Trial 9	223.63	309.61	85.98	0.7407
Trial 10	216.63	309.61	92.98	0.7352
Trial 11	259.98	309.61	49.62	0.5540
Trial 12	157.19	309.61	152.42	0.9044
Trial 13	229.49	309.61	80.12	0.7024
Trial 14	209.51	309.61	100.10	0.7530
Trial 15	206.51	309.61	103.10	0.7601
Trial 16	239.05	309.61	104.21	0.7536
Trial 17	205.40	309.61	104.21	0.7917
Trial 18	233.94	309.61	75.67	0.6884
Trial 19	218.95	309.61	90.66	0.8098