Transgenic Rat Model of Huntington’s Disease: A Histopathological Study and Correlations with Neurodegenerative Process in the Brain of HD Patients

Figure 10

In HD human brain, significant “reactive” astrogliosis develops with the progression of NDP (b, c) in comparison with control brain (a); also the fine GFAP⁺ processes become numerous and of characteristic arborization; specific terminal swellings are in most of the densely GFAP⁺ processes; although the amount of S100β ⁺/GFAP^- is not significantly influenced by NDP, the regressive changes (shrinkage) affect also S100β ⁺ cells. (a) Control (♂/56), (b) HD duration 8 years, grade 3 (♂/38), and (c) HD duration 20 years, grade 4 (♀/52). Anti-GFAP (red) + anti-S100β (green) + DAPI (blue). Bar 20 μm.

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