Transgenic Rat Model of Huntington’s Disease: A Histopathological Study and Correlations with Neurodegenerative Process in the Brain of HD Patients
Figure 6
(a) In young control animals (2 months old), synapses within the neuropil are very numerous, fine and of uniform size; (b) the most conspicuous alteration in old (here 18 months) tgHD rats is variable size and enlargement (coarsening) of most of synapses; however, also their decreased number participating in loosening of neuropil is evident. Anti-synaptophysin counterstained with 0.1% methyl green. Bar 10 μm.
