Transgenic Rat Model of Huntington’s Disease: A Histopathological Study and Correlations with Neurodegenerative Process in the Brain of HD Patients
Figure 7
(a) Synapses in intact (control, ♂/56) human brain are (like in rats) uniform and densely accumulated within the neuropil; (b) they also become coarser and of variable size with the progression of NDP in HD patients (here ♀/52, grade 4, duration 20 years); continuous decrease in their number significantly participates in rarefaction of the neuropil, most prominent in terminal stage of NDP. Anti-synaptophysin counterstained with 0.1% methyl green. Bar 10 μm.
