Caspase Mediated Synergistic Effect of Boswellia serrata Extract in Combination with Doxorubicin against Human Hepatocellular Carcinoma

Table 1

Result of Isobolographic analysis showing combination index (CI).

Treatment	CI
	HepG2	Hep3B
DOX + bs10	0.76	0.79
DOX + bs20	0.54	0.56
DOX + bs30	0.53	0.55

The CI values represent mean of four experiments. CI.1.3: antagonism; CI 1.1–1.3: moderate antagonism; CI 0.9–1.1: additive effect; CI 0.8–0.9: slight synergism; CI 0.6–0.8: moderate synergism; CI 0.4–0.6: synergism; and CI 0.2–0.4: strong synergism. DOX + bs10-doxorubicin 1 M + Boswellia extract 10 g/mL; DOX + bs20-doxorubicin 1 M + Boswellia extract 20 g/mL; and DOX + bs30-doxorubicin 1 M + Boswellia extract 30 g/mL.