CGP 35348, GABAB Receptor Antagonist, Has a Potential to Improve Neuromuscular Coordination and Spatial Learning in Albino Mouse following Neonatal Brain Damage
Table 1
Comparison of open field test parameters between CGP 35348 and saline treated male and female albino mice following hypoxia ischemia encephalopathy.
Parameters
Control male mice()
CGP 35348 treated male mice()
value
Control female mice ()
CGP 35348 treatedfemale mice()
value
Distance (m)
19.3 ± 0.6
18.7 ± 0.6
0.83
29 ± 1
18 ± 1
0.07
Mean speed (m/s)
0.03 ± 0.00
0.03 ± 0.00
0.82
0.05 ± 0.00
0.03 ± 0.00
0.08
Time mobile (sec)
436 ± 7.5
461 ± 5.9
0.42
518 ± 5
412 ± 10
0.03*
Time immobile (sec)
163 ± 7.5
139 ± 5.9
0.42
82 ± 5
188 ± 10
0.03*
Mobile episodes
32.4 ± 0.6
32.9 ± 0.9
0.89
21 ± 1
34 ± 1
0.07
Immobile episodes
31.6 ± 0.6
32.0 ± 0.9
0.91
20 ± 1
34 ± 1
0.06
Max. speed (m/s)
0.24 ± 0.01
0.25 ± 0.00
0.71
0.29 ± 0.01
0.25 ± 0.01
0.59
Rotations
21.4 ± 0.5
24.5 ± 0.5
0.22
36 ± 1
24 ± 1
0.18
Clockwise rotations
12.4 ± 0.3
12.4 ± 0.3
1.0
17 ± 1
11 ± 1
0.41
Anticlockwise rotation
9.0 ± 0.3
12.1 ± 0.4
0.90
18 ± 1
12 ± 1
0.09
Data is given as mean ± standard error of mean. value indicates the results of two-sample -test. is nonsignificant; is the least significant (*).
