Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 296498, 7 pages
http://dx.doi.org/10.1155/2014/296498
Clinical Study

Coating of Mesh Grafts for Prolapse and Urinary Incontinence Repair with Autologous Plasma: Exploration Stage of a Surgical Innovation

1Department of Urology, Lukas Hospital, 41464 Neuss, Germany
2German Centre for Assessment and Evaluation of Innovative Techniques in Medicine (DZITM), 41464 Neuss, Germany
3Department of Surgery, Lukas Hospital, 41464 Neuss, Germany
4ITERA (International Tissue Engineering Research Association), 2000 Antwerpen, Belgium
5Department of Surgery, University of Antwerpen, 2000 Antwerpen, Belgium
6German Centre for Implant-Pathology, 52351 Düren, Germany
7Department of Experimental Surgery, University of Szeged, H-6720 Szeged, Hungary

Received 27 June 2014; Accepted 17 August 2014; Published 16 September 2014

Academic Editor: Uwe Klinge

Copyright © 2014 Dimitri Barski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. Optimized biocompatibility is a major requirement for alloplastic materials currently applied for stress urinary incontinence (SUI) and pelvic organ prolapse (POP) repair. In the preliminary studies the mesh modification by coating with autologous plasma resulted in the increased adherence score in vitro and improved biocompatibility in an animal model. The first use of plasma coated meshes in human is presented. Materials and Methods. Between 04/2013 and 05/2014, 20 patients with the indication for SUI and POP repair were selected in a single institution. The applied meshes were modified by autologous plasma coating prior to implantation. A retrospective chart review for peri- and early postoperative complications was performed. Functional outcome and QoL were evaluated pre- and postoperatively. Results. The functional outcome and QoL improved significantly in all groups. Two reoperations (Grade IIIB) with the release of TVT-mesh in anesthesia due to the obstruction were needed. No other severe complications were registered. Conclusion. For the first time we applied a mesh modification in a human setting according to IDEAL criteria of surgical innovations. The procedure of mesh coating with autologous plasma is safe and a prospective randomized trial proving a positive effect of plasma coating on the biocompatibility and morbidity outcome with long-term registry is planned.