Integration Analysis of MicroRNA and mRNA Expression Profiles in Human Peripheral Blood Lymphocytes Cultured in Modeled Microgravity
Table 1
Selected GO terms of biological processes significantly affected by microgravity. The complete list of GO terms can be found in Supplementary Table S6.
GO:ID
Term
Count
value
Fold enrichment
FDR
GO:0045087
Innate immune response
25
2,42 × 10−5
2,566978193
0,040412626
GO:0009966
Regulation of signal transduction
88
1,67 × 10−4
1,471577879
0,27973741
GO:0048468
Cell development
62
1,71 × 10−4
1,610338849
0,285253218
GO:0045595
Regulation of cell differentiation
54
2,68 × 10−4
1,648
0,448057857
GO:0006954
Inflammatory response
41
3,23 × 10−4
1,787513228
0,539044451
GO:0080134
Regulation of response to stress
37
5,43 × 10−4
1,806696296
0,90478009
GO:0010646
Regulation of cell communication
95
8,22 × 10−4
1,380599647
1,366092587
GO:0048513
Organ development
139
8,22 × 10−4
1,290910116
1,366713032
GO:0042060
Wound healing
26
8,38 × 10−4
2,025910165
1,393334889
GO:0007165
Signal transduction
198
0,001398603
1,211224944
2,313943814
GO:0001817
Regulation of cytokine production
27
0,001406003
1,926233766
2,326052387
GO:0048514
Blood vessel morphogenesis
26
0,001709187
1,93009009
2,820918727
GO:0001817
Regulation of cytokine production
15
0,001406003
1,926233766
2,326052387
GO:0007399
Nervous system development
88
0,002097026
1,359812471
3,450524099
GO:0022603
Regulation of anatomical structure morphogenesis
28
0,002408369
1,831111111
3,953172097
GO:0048870
Cell motility
33
0,002838826
1,710188679
4,64407324
GO:0048522
Positive regulation of cellular process
159
0,003551259
1,221594406
5,777298149
GO:0002684
Positive regulation of immune system process
31
0,003855111
1,711490787
6,256755641
GO:0050865
Regulation of cell activation
26
0,003880839
1,819447983
6,297247375
GO:0051174
Regulation of phosphorus metabolic process
51
0,003964604
1,486259947
6,428964883
GO:0001944
Vasculature development
28
0,003981783
1,767969349
6,455956993
GO:0043066
Negative regulation of apoptosis
41
0,004040803
1,56952381
6,548633436
GO:0010941
Regulation of cell death
83
0,004115909
1,341019608
6,666445839
GO:0009617
Response to bacterium
22
0,004991824
1,9032021
8,030143455
GO:0043067
Regulation of programmed cell death
82
0,00552374
1,328770895
8,849108723
GO:0008285
Negative regulation of cell proliferation
40
0,00576007
1,54741784
9,210770389
GO:0010557
Positive regulation of macromolecule biosynthetic process