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BioMed Research International
Volume 2014, Article ID 296986, 9 pages
http://dx.doi.org/10.1155/2014/296986
Review Article

Mycobacterium tuberculosis P-Type ATPases: Possible Targets for Drug or Vaccine Development

Chemistry Department, Faculty of Sciences, Universidad Nacional de Colombia, Carrera 30 No. 45-03, Bogotá, Cundinamarca 111321, Colombia

Received 7 February 2014; Accepted 23 June 2014; Published 10 July 2014

Academic Editor: Armando Acosta

Copyright © 2014 Lorena Novoa-Aponte and Carlos Yesid Soto Ospina. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tuberculosis (TB) has been the biggest killer in the human history; currently, Mycobacterium tuberculosis (Mtb) kills nearly 2 million people each year worldwide. The high prevalence of TB obligates the identification of new therapeutic targets and the development of anti-TB vaccines that can control multidrug resistance and latent TB infections. Membrane proteins have recently been suggested as key targets for bacterial viability. Current studies have shown that mycobacteria P-type ATPases may play critical roles in ion homeostasis and in the response of mycobacteria to toxic substances in the intraphagosomal environment. In this review, we bring together the genomic, transcriptomic, and structural aspects of the P-type ATPases that are relevant during active and latent Mtb infections, which can be useful in determining the potential of these ATPases as drug targets and in uncovering their possible roles in the development of new anti-TB attenuated vaccines.