Mycobacterium tuberculosis P-Type ATPases: Possible Targets for Drug or Vaccine Development

Figure 1

Structural organization of the five P-type ATPase domains. M. tuberculosis CtpF tertiary structure model, generated using the SWISS-MODEL server (http://swissmodel.expasy.org/) in automated mode and the structure of the Sarco(endo)plasmic reticulum calcium ATPase 1 from Oryctolagus cuniculus (PDB accession number 3AR4) as template. The model was modified using the PPM server to include the possible location of the lipid bilayer, which is displayed in cyan dummies that correspond to the location of the carbonyl groups in the bilayer.