BioMed Research International / 2014 / Article / Tab 1 / Review Article
Subunit Composition of Neurotransmitter Receptors in the Immature and in the Epileptic Brain Table 1 Subunit composition of glutamate and GABA receptors in the immature brain.
Author and year Study design Substudy features (if applicable) AMPA NMDA GABA Animal models of the immature brain without seizures Kumar et al., 2002 [9 ] Neocortical pyramidal neurons in excitatory layer 5, immature nonepileptic rats (compared to mature rats) GluA2 ↓
Talos et al., 2006 [11 ]
Immature nonepileptic rats (compared to mature rats) White matter GluA1 ↓ Gray matter GluA1 ↑ Monyer et al., 1994 [10 ] Immature nonepileptic rats (compared to mature rats). Various areas in the brain GluN2A ↓ Wong et al., 2002 [13 ] Immature nonepileptic rats (compared to mature rats). Various areas in the brain GluN3A ↑ Dunning et al., 1999 [22 ] Functional studies of neurons from somatosensory cortex of neonatal mice Data from the human immature brain without seizures
Talos et al., 2006 [12 ] Autopsy samples from newborns of different gestational ages (compared to adult standard). Parietooccipital lobe tissue. Death due to nonneurological disorders White matter GluA2 ↓ Gray matter GluA1 ↑
Brooks-Kayal and Pritchett, 1993 [7 ] Autopsy samples from patients without neurological disease of different ages (36 gestational weeks to 81 years). Frontal cortex and cerebellum
