Table 4: Factors with impact on patients’ survival (Cox regression analysis).

    Disease specific survivalOverall survival
      valueHR95% CIAdjusteda   valueAdjusted HR95% CI valueHR95% CIAdjusteda   valueAdjusted HR95% CI

Gender                
 FemaleReferentReferentReferentReferent
 Male0.2770.3260.043–2.4580.3560.3850.051–2.9290.0990.3000.072–1.2530.1260.3270.078–1.370
Age0.0350.9720.920–1.026NA0.8921.0030.963–1.044NA
Tobacco                
 NonsmokerReferentReferentReferentReferent
 Smoker0.2180.6230.293–1.3230.4350.7400.347–1.5760.0190.5050.285–0.8940.0210.4960.274–0.898
Alcohol                
 NoReferentReferentReferentReferent
 Yes0.9711.0100.586–1.7410.8371.0590.615–1.8220.5051.5060.452–5.0170.8640.9660.647–1.440
Tumor size                
 T1 + T2ReferentReferentReferentReferent
 T3 + T40.1871.9300.727–5.1270.1512.0610.768–5.5290.0272.1921.092–4.3960.0212.2961.135–4.646
Nodal status                
 N0ReferentReferentReferentReferent
 N1–N30.0913.5650.959–1.0330.0206.0351.334–27.3050.1881.7000.771–3.7470.0642.2280.995–5.194
Tumor grade                
 G1ReferentReferentReferentReferent
 G2 + G30.9801.0060.627–1.6160.9321.0180.683–1.5160.4081.1020.875–1.3880.4981.0800.864–1.350
Tumor location                
 OropharyngealReferentReferentReferentReferent
 Oral0.6311.3630.386–4.8140.9931.0060.277–3.6530.8120.8810.309–2.510.5080.6970.239–2.029
Recurrence                
 NoReferentReferentReferentReferent
 Yes0.000112.2084.591–32.460.00110.5033.843–28.7050.00016.9363.372–14.2680.00016.7113.192–14.111
Tregs 0.0540.9170.840–1.0010.0610.9200.843–1.0040.4590.9840.943–1.0270.5250.9860.956–1.029
Tregs                
 LowReferentReferentReferentReferent
 High0.0980.4280.157–1.1710.0850.4130.151–1.1290.0970.5630.286–1.1090.1030.5680.269–1.123
CD4+0.9291.0030.946–1.0630.7720.9910.936–1.0510.8150.9950.956–1.0360.6150.9900.951–1.030
CD8+0.2601.0320.956–1.1051.0911.0270.972–1.0850.1991.0260.987–1.0660.23610.0230.985–1.063
CD4+CD8+sum0.2021.0380.980–1.0980.4721.0210.964–1.0820.2721.0230.982–1.0650.4431.0120.974–1.061
CD4+/CD8+0.2740.7010.371–1.3250.2460.6930.373–1.2880.1540.7350.481–1.1120.1290.7250.479–1.098
CD8+/Tregs0.0011.2111.098–1.3360.0011.1871.074–1.3110.0041.1501.045–1.2660.0121.1361.029–1.253
CD190.8510.9910.905–1.0850.9531.0030.921–1.0910.6170.9860.924–1.0520.8530.9940.932–1.060
CD3–56+16+0.0200.8850.798–0.9810.0620.9050.815–1.0050.2950.9860.911–1.0290.4090.9740.915–1.037
HPV DNA             
 NegativeReferent   Referent    
 Positive0.0570.3350.109–1.033 0.1250.5820.292–1.162

adjusted for HPV and age, HR: hazard ratio 95% CI: confidence interval; : probability.