Gene Expression Changes Induced by Trypanosoma cruzi Shed Microvesicles in Mammalian Host Cells: Relevance of tRNA-Derived Halves
Figure 4
Pathways affected by EVs treatment. HeLa cells were exposed to 160 ng of EVs fraction for two hours and analyzed at 6, 24, and 72 hours. (a) Table showing the cellular pathways affected by EVs treatment. The corresponding time points and the analysis tool used are included. (b) Heat map representation of the modified genes involved in these pathways (indicated at the left of the figure) for each time point (indicated at the top). For the Rho GTPase pathway the role of the modified genes is expressed as GDI (guanine nucleotide dissociation inhibitor), GAP (GTPase-activating protein), or GEF (guanine nucleotide exchange factor). MMP: matrix metalloproteinase; TIMP: tissue inhibitor of metalloproteinases; IL-1R: interleukin 1 receptor; IL-1R AP: interleukin 1 receptor adaptor protein; CCL2: CC-chemokine ligand 2; CXCL2: CXC-chemokine ligand 2; IL-6: interleukin 6; IL-18: interleukin 18; CARD6: caspase recruitment domain family, member 6. Red: underexpressed; green: overexpressed. Experiments were performed by duplicate on three independent samples.
