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BioMed Research International
Volume 2014, Article ID 306718, 6 pages
Research Article

The Antileukemia Activity of Natural Product HQ17(3) Is Possibly Associated with Downregulation of miR-17-92 Cluster

1Institute of Biotechnology in Medicine, Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei 11221, Taiwan
2Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei 11217, Taiwan
3Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei 11217, Taiwan

Received 6 March 2014; Revised 23 June 2014; Accepted 4 July 2014; Published 22 July 2014

Academic Editor: Francesco Onida

Copyright © 2014 Ya-Chun Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

U937 cells were cultured with/without 3 μM of HQ17(3) for 24 h. The miRNA levels were detected by an Agilent human miRNA array R12. The raw data of microarray is presented here. For those miRNA levels shown apparent change (>1.43 fold or <0.7 fold, and signal >60) after HQ17(3) treatment, 4 of them were up-regulated (marked in red) and 21 of them are down-regulated (marked in blue).

  1. Supplementary Material