Pharmacology of Hallucinations: Several Mechanisms for One Single Symptom?

Figure 1

5HT2AR/D2R/NMDAR interactions. Simplified version of the Geyer and Vollenweider model of psychosis [25], which supposes a disruption in the cortico-striato-thalamo-cortical loops. This model tries to connect 5HT2R, D2R, and NMDAR in a unified neurobiological system which could be impaired in psychosis. Abbreviations. mPFC: medial prefrontal cortex; VTA: ventral tegmental area; NMDAR: N-methyl-D-aspartate receptor; D2R: dopamine-2 receptor; 5HT2R: 5-hydroxytryptamine-2A receptor.