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BioMed Research International
Volume 2014, Article ID 308690, 10 pages
Review Article

Calorie Restriction in Mammals and Simple Model Organisms

Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi (DiBiMeF), Università di Palermo, Via Divisi 83, 90133 Palermo, Italy

Received 3 February 2014; Revised 13 April 2014; Accepted 21 April 2014; Published 6 May 2014

Academic Editor: Giuseppe Passarino

Copyright © 2014 Giusi Taormina and Mario G. Mirisola. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Calorie restriction (CR), which usually refers to a 20–40% reduction in calorie intake, can effectively prolong lifespan preventing most age-associated diseases in several species. However, recent data from both human and nonhumans point to the ratio of macronutrients rather than the caloric intake as a major regulator of both lifespan and health-span. In addition, specific components of the diet have recently been identified as regulators of some age-associated intracellular signaling pathways in simple model systems. The comprehension of the mechanisms underpinning these findings is crucial since it may increase the beneficial effects of calorie restriction making it accessible to a broader population as well.