Rosiglitazone Increases Cerebral Klotho Expression to Reverse Baroreflex in Type 1-Like Diabetic Rats

Figure 2

Effect of recombinant klotho (rKl) on the sensitivity of the baroreflex in STZ-diabetic rats. The effect of rKl or rat IgG (IgG) on the mean arterial pressure (MAP, mmHg), heart rate (HR, bpm), and baroreflex sensitivity (BRS, bpm/mmHg) in response to phenylephrine (PE, 8 μg/kg, IV) (a) or (SNP, 50 μg/kg, IV) (b) in each group; Con means control, STZ shows STZ-diabetic rats, STZ + IgG is IgG-treated group and STZ + rKl indicates the recombinant klotho-treated STZ group. The quantification is indicated as the means with the SE (𝑛=8 per group) in each column shown in the lower panel. ^∗∗𝑃<0.01 and ^∗∗∗𝑃<0.001 compared to Wistar.

(a)

(b)