Andrographolide Induces Apoptosis of C6 Glioma Cells via the ERK-p53-Caspase 7-PARP Pathway

Figure 7

AND prevented the growth of C6 glioma in vivo. ((a)–(c)) The ears of ICR mice were injected with C6 cells with or without 20 AND μM for 5 days. (a) An example of cell injection alone ear (C6) and AND plus cells injection ear (C6 + AND). (b) Tumors isolated from (a) at day 5. (c) Quantitation of tumor weights. 𝑁=3, ^∗∗𝑃<0.01 compared to the C6 group. ((d)–(g)) The ears of ICR mice were injected with C6 cells for 3 days (d) and then received injection with PBS (PBS) or 20 AND μM (AND) twice at day 3 and day 6, and pictures were taken at day 3 (d) and day 9 (f). (e) Tumors isolated from (f) at day 9. (g) Quantitation of tumor weights. 𝑁=3, ^∗∗𝑃<0.01 compared to the PBS-group.

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