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BioMed Research International
Volume 2014, Article ID 312847, 15 pages
http://dx.doi.org/10.1155/2014/312847
Research Article

Andrographolide Induces Apoptosis of C6 Glioma Cells via the ERK-p53-Caspase 7-PARP Pathway

1Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, No. 7, Zhongshan South Road, Zhongzheng District, Taipei City 100, Taiwan
2Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, 1-1 Jen-Ai Road, Taipei 10051, Taiwan
3Department of Biology and Anatomy, National Defense Medical Center, No. 161, Section 6, Minquan East Road, Neihu District, Taipei City 114, Taiwan
4Division of Nephrology, Department of Internal Medicine, Far Eastern Memorial Hospital, No. 21, Section 2, Nanya South Road, Banqiao District, New Taipei City 220, Taiwan

Received 19 April 2014; Accepted 27 May 2014; Published 5 August 2014

Academic Editor: Dan-Ning Hu

Copyright © 2014 Shih-Hung Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

AND and DAPI were purchased from Sigma. DEVD, 3AB, DTT, and NAC were purchased from BioMol. pifithrin-α is purchased from Enzo. LEHD is purchased from Biovision. PD98059 was purchased from Cell Signaling Technology. Annexin V is from the Aoptosis Detection kit (Strong Biotech Corporation, AV050, Taipei, Taiwan). c-caspase 7, c-PARP, p-P53, and P53 antibodies were purchase from Cell Signaling Technology. GAPDH was purchased from GeneTex.

  1. Supplementary Material