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BioMed Research International
Volume 2014, Article ID 316204, 9 pages
Review Article

Neuroprotective Effects of Lipoxin A4 in Central Nervous System Pathologies

1Departmento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, 88049-900 Florianópolis, SC, Brazil
2Centro de Inovação e Ensaios Pré-Clínicos (CIEnP), Av. Luiz Boiteux Piazza, 1302-Canasvieiras, 88056-000 Florianópolis, SC, Brazil

Received 19 June 2014; Accepted 12 August 2014; Published 9 September 2014

Academic Editor: Alexandre de Paula Rogerio

Copyright © 2014 Alessandra Cadete Martini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Many diseases of the central nervous system are characterized and sometimes worsened by an intense inflammatory response in the affected tissue. It is now accepted that resolution of inflammation is an active process mediated by a group of mediators that can act in synchrony to switch the phenotype of cells, from a proinflammatory one to another that favors the return to homeostasis. This new genus of proresolving mediators includes resolvins, protectins, maresins, and lipoxins, the first to be discovered. In this short review we provide an overview of current knowledge into the cellular and molecular interactions of lipoxins in diseases of the central nervous system in which they appear to facilitate the resolution of inflammation, thus exerting a neuroprotective action.