Neuroprotective Effects of Lipoxin A4 in Central Nervous System Pathologies

<table>Schematic representation of the main biochemical pathways that mediate the production of proresolution lipid mediators. Arachidonic acid is derived from omega (<i>ω</i>)-6 and can be converted into lipoxins by lipoxygenases action. Omega (<i>ω</i>)-3 originates EPA-derived resolvins series E and DHA-derived resolvins series D, protectins, and maresins. COX: cycloxygenase; LOX: lipoxygenase; HETE: eicosatetraenoic acid; acCOX-2: acetylated cyclooxygenase-2; CYP: cytochrome P450; LXA4: lipoxin A4; RvEs: resolvins series E; RvD: resolvins series D; MaRs: maresins; PDs: protectins.</table>

BioMed Research International

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Figure 1

Figure 1: Neuroprotective Effects of Lipoxin A4 in Central Nervous System Pathologies 