Research Article
A New Nested Allele-Specific Multiplex Polymerase Chain Reaction Method for Haplotyping of VKORC1 Gene to Predict Warfarin Sensitivity
Table 3
Genotype frequency of individual VKORC1 SNPs and haplotype frequency in 93 subjects.
| | | Number of patients (%) | | | Homozygous wild type | Heterozygous | Homozygous mutant |
| | VKORC1 381 (C>T) | 51 (54.84) | 33 (35.48) | 9 (9.68) | | VKORC1 861 (C>A) | 91 (97.85) | 0 (0) | 2 (2.15) | | VKORC1 5808 (G>A) | 92 (98.92) | 1 (1.08) | 0 (0) | | VKORC1 9041 (T>G) | 51 (54.84) | 33 (35.48) | 9 (9.68) |
| | | Number of patients (%) |
| | H1H1 | 50 (53.76) | | H1H2 | 1 (1.08) | | H1H7a | 1 (1.08) | | H1H7 or H1H9a | 31 (33.33) | | H1H9 | 1 (1.08) | | H7H7 | 8 (8.6) | | H8H9 | 1 (1.08) |
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“H1H7 or H1H9” was considered as “H1H7,” in concordance with previous investigation findings, where H1H9 was uncommon in Asia.
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