Review Article
The Role of microRNAs in the Regulation of Apoptosis in Lung Cancer and Its Application in Cancer Treatment
Table 1
Upregulated apoptosis-associated miRNAs in lung cancer.
| MicroRNA | Target genes | Function | Cell lines | In vivo models | Citation |
| miR-197 | BMF, NOXA | Repress p53-dependent apoptotic cascade miR inhibition decreases cell viability miR inhibition impairs cell growth and anchorage-independent colony formation | A549, Calu-1, NIH-H460, NCI-H1299 | Nude mice | [35] |
| miR-21 | SPRY1, SPRY2, BTG2, PDCD4, APAF1, FasL, RHOB | Enhance tumor proliferation and survival Inhibit apoptosis miR deletion suppresses Ras-driven transformation | N/T |
K-rasLA2 mice CAG-miR-21 transgenic mice CAG-miR-21; K-rasLA2 compound mutant mice | [37] |
| miR-212 | AChE | Prevent apoptosis Maintain cell proliferation capacity Modulate CDDP-induced NSCLC cell apoptosis | HEK-293T, NCI-H520, NCI-H460, SK-MES-1, BEAS-2B | Nude mice | [43] |
| miR-17-5p, miR-20a | E2F1 | miR inhibition reduces of cell growth. miR inhibition induces apoptosis and increases proportions of sub-G1 populations. | Calu-6, A549, ACC-LC-172 | N/T | [45] |
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N/D: not determined; N/T: not tested.
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