MicroRNA Target genes Function Cell lines In vivo modelsCitation miR-7 BCL-2 Suppress cell proliferation and induce cell apoptosis Inhibit cancer cell migration in vitro ā Reduce tumorigenicity in vivo A549, NCI-H1299, NCI-H1355, NCI-H460, MRC-5, HEK-293T Nude mice [51 ] miR-198 FGFR1 Inhibit lung cancer cells proliferation Enhance cell apoptosis Inhibits growth of tumor graft in nude mouse A549, NCI-H460 Athymic BALB/c nude mice. [69 ] miR-451 RAB14 Inhibit in vitro proliferation and enhance apoptosis Decrease phosphorylation of AKT and increased BAX or Bad protein level Associated with in vivo proliferation capacity A549, SPC-A1, NCI-H520 Athymic BALB/c nude mice. [75 ] miR-192 RB1 Inhibit cell proliferation and promotes cell apoptosis Arrest cell in G1 phase Inhibit tumorigenesis in vivo A549, NCI-H460, 95D Athymic BALB/c nude mice. [76 ] miR-335 BCL-W, SP1 Suppress proliferation and invasion ability of cells Induce apoptosis Suppress metastasis and invasiveness of cells A549, NCI-H1299 N/T [52 ] miR-608 N/D Increase cell death in Bcl-xL silenced cells A549, SK-LU-1 N/T [55 ] miR-203 PKC
Decrease cell proliferation Promote cell apoptosis, but this effect only partially relies on its downregulation of PKC
A549 N/T [61 ] miR-413 PKC
Inhibit cell proliferation and enhance apoptosis A549, Calu-1 N/T [63 ] miR-146a EGFR Inhibit cell growth and induces cell apoptosis Suppress motility Enhance cell proliferation inhibitory effect of TKIs and cetuximab NCI-H358, NCI-H1650, NCI-H1975, NCI-H292, HCC827 N/T [70 ] miR-26a EZH2 Inhibit cell proliferation in vitro Block G1/S phase transition and induced apoptosis Decreased metastasis capacity and invasion SPC-A1, A549, SK-MES-1 N/T [71 ]