The Role of microRNAs in the Regulation of Apoptosis in Lung Cancer and Its Application in Cancer Treatment

Table 2

Downregulated apoptosis-associated miRNAs in lung cancer.

MicroRNA	Target genes	Function	Cell lines	In vivo models	Citation
miR-7	BCL-2	Suppress cell proliferation and induce cell apoptosis; Inhibit cancer cell migration in vitro; Reduce tumorigenicity in vivo	A549, NCI-H1299, NCI-H1355,; NCI-H460, MRC-5, HEK-293T	Nude mice	[51]
miR-198	FGFR1	Inhibit lung cancer cells proliferation; Enhance cell apoptosis; Inhibits growth of tumor graft in nude mouse	A549,; NCI-H460	Athymic BALB/c nude mice.	[69]
miR-451	RAB14	Inhibit in vitro proliferation and enhance apoptosis; Decrease phosphorylation of AKT and increased BAX or Bad protein level; Associated with in vivo proliferation capacity	A549, SPC-A1,; NCI-H520	Athymic BALB/c nude mice.	[75]
miR-192	RB1	Inhibit cell proliferation and promotes cell apoptosis; Arrest cell in G1 phase; Inhibit tumorigenesis in vivo	A549,; NCI-H460,; 95D	Athymic BALB/c nude mice.	[76]
miR-335	BCL-W, SP1	Suppress proliferation and invasion ability of cells; Induce apoptosis; Suppress metastasis and invasiveness of cells	A549, NCI-H1299	N/T	[52]
miR-608	N/D	Increase cell death in Bcl-xL silenced cells	A549, SK-LU-1	N/T	[55]
miR-203	PKC𝛼	Decrease cell proliferation; Promote cell apoptosis, but this effect only partially relies on its downregulation of PKC𝛼	A549	N/T	[61]
miR-413	PKC𝜀	Inhibit cell proliferation and enhance apoptosis	A549, Calu-1	N/T	[63]
miR-146a	EGFR	Inhibit cell growth and induces cell apoptosis; Suppress motility; Enhance cell proliferation inhibitory effect of TKIs and cetuximab	NCI-H358,; NCI-H1650,; NCI-H1975,; NCI-H292, HCC827	N/T	[70]
miR-26a	EZH2	Inhibit cell proliferation in vitroBlock G1/S phase transition and induced apoptosis; Decreased metastasis capacity and invasion	SPC-A1, A549,; SK-MES-1	N/T	[71]

N/D: not determined; N/T: not tested.