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BioMed Research International
Volume 2014 (2014), Article ID 320767, 6 pages
Review Article

Streamlining Cutaneous Melanomas in Young Women of the Belgian Mosan Region

1Department of Dermatopathology, Unilab Lg, University Hospital of Liège, 4000 Liège, Belgium
2Dermatology Unit, Diagnostic Centre, 4800 Verviers, Belgium
3INTELSIG Laboratory, Montefiore Institute, University of Liège, 4000 Liège, Belgium

Received 16 January 2014; Accepted 24 January 2014; Published 25 February 2014

Academic Editor: Gérald E. Piérard

Copyright © 2014 Trinh Hermanns-Lê and Sébastien Piérard. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sporadic cutaneous melanoma (SCM) has shown a dramatic increase in incidence in Caucasian populations over the past few decades. A particular epidemiological increase was reported in women during their childbearing age. In the Belgian Mosan region, a progressive unremitting increase in SCM incidence was noticed in young women for the past 35 years. The vast majority of these SCMs were of the superficial type without any obvious relationship with a large number of melanocytic nevi or with signs of frequent and intense sunlight exposures as disclosed by the extent in the mosaic subclinical melanoderma. A series of investigations pointed to a possible relationship linking the development of some SCM to the women hormonal status including the effect of hormonal disruptors. These aspects remain, however, unsettled and controversial. It is possible to differentiate and clearly quantify the SCM shape, size, scalloped border, and variegated pigmentation using computerized morphometry as well as fractal and multifractal methods.