Figure 1: Areas of significant gray matter differences (including correction for age and total intracranial volume, less than 1 false-positive cluster expected, ) across the three groups (normal volunteers and responder and nonresponder schizophrenia patients) at ANCOVA, superimposed onto the average of the normalized GM volumes. Right side of the brain is at the observer’s right. GM differences among the three groups involve mainly the frontal lobes bilaterally. Superior and middle frontal gyri are involved on the left, extending into the pre- and postcentral gyri, while on the right mainly middle frontal gyrus and insula are involved. Additionally, right medial temporal lobe (mainly amygdala) is involved.