MPINet: Metabolite Pathway Identification via Coupling of Global Metabolite Network Structure and Metabolomic Profile

Figure 4

Global-weighted human metabolite network for several pathways identified by MPINet. The yellow node represents differential metabolites. Node size is proportional to the CGNB score of metabolites in (a) and (b). (a) Two metastatic prostate cancer-related pathways: “tryptophan metabolism” and “arachidonic acid metabolism.” (b) Three type 2 diabetes-related pathways: “primary bile acid biosynthesis,” “valine, leucine, and isoleucine degradation,” and “tyrosine metabolism.” (c) A global view of the interaction between the 21 type 2 diabetes-associated pathways. The edges between two pathways are displayed when the average GCS value between metabolite sets in the two pathways is greater than the median GCS value. Edge-line width is proportional to the average GCS value. Orange nodes represent pathways known to be related to type 2 diabetes. The red circle in the network corresponds to the three pathways in (b).