MPINet: Metabolite Pathway Identification via Coupling of Global Metabolite Network Structure and Metabolomic Profile
Table 1
Top-ranked 15 pathways in MPINet and their ranks in MetPA.
Pathway name
FDR-N
R-P
I-P
Arginine and proline metabolism*
8.15E − 09
6
0.21
Caffeine metabolism
12
0.17
Tryptophan metabolism*
5.75E − 07
17
0.14
Primary bile acid biosynthesis
17
0.14
Ubiquinone and other terpenoid-quinone biosynthesis
33
0.05
Steroid hormone biosynthesis*
2.65E − 05
38
0.03
Cyanoamino acid metabolism
0.00019
12
0.17
Tyrosine metabolism*
0.00034
34
0.04
Nicotinate and nicotinamide metabolism
0.0004
26
0.07
Linoleic acid metabolism
0.0012
1
0.62
Cysteine and methionine metabolism
0.0039
9
0.19
Arachidonic acid metabolism*
0.0039
—
—
Porphyrin and chlorophyll metabolism
0.0043
34
0.04
Inositol phosphate metabolism*
0.007
17
0.14
Valine, leucine, and isoleucine degradation*
0.0081
26
0.07
FDR-N: FDR values of pathways in MPINet; R-P and I-P: ranks and impact scores for MetPA. Bold pathways have been well reported to be related with cancer. Ranks of pathways marked by asterisk in MPINet surpass that in MetPA.
