Cardioprotection: A Review of Current Practice in Global Ischemia and Future Translational Perspective

Figure 3

Dance of neutrophils. Leukocyte capture, rolling, adhesion, and transmigration through the endothelial cell barrier. PSGL, P selectin glycoprotein ligand; LSG, L selectin glycoprotein ligand; ICAM, intercellular adhesion molecule. Initial capture of leukocytes is mediated via selectin (endothelial P/E selectin binds PSGL); tight adhesion is mediated via integrins (neutrophil beta-2, leukocyte function associated antigen, CD11/CD18 binds ICAM).