miRNA Transcriptome of Hypertrophic Skeletal Muscle with Overexpressed Myostatin Propeptide

Table 4

Abundant differentially expressed miRNAs their targets and predicted pathways for targets.

	miRNAs	MAPK signaling pathway	TGF-β signaling pathway	mTOR signaling Pathway
1	miR-27b	EGFR, RPS6KA5, KRAS, SOS1,; MAP2K4, MKNK2, CACNG2, FGF1,; RAPGEF2, CACNA1A, ACVR1C, PRKCB	SMAD9, IFNG, RPS6KB1, SMAD1, ACVR1C	PDPK1, RPS6KB1, RICTOR
2	miR-16a	CACNA2D1, FGF9, NF1, GNA12,; RAF1, MKNK1, MAPK8, AKT3		PIK3R1, AKT3
3	miR-21a	MAP3K7, NTF3, FASL, MAPK10, DUSP8	PITX2
4	miR-23a	PTPN7, MAP4K4, MAP3K5, PAK2,; RRAS2, CACNA1E, FAS, STK4, CHUK	SMAD5, SMURF2	PIK3CB, PIK3R3
5	miR-26a	RPS6KA6, RAP1A		RPS6KA6, ULK1, ULK2
6	miR-29b	DUSP2, GNG12		VEGFA, IGF1, EIF4E2
7	miR-30b	TAOK1, RASA1, MAP3K12		PIK3CD, PRKAA2
8	miR-30c	TAOK1, RASA1, MAP3K12		PIK3CD, PRKAA2
9	miR-30d	TAOK1, RASA1, MAP3K12		PIK3CD, PRKAA2
10	miR-30e	TAOK1, RASA1, MAP3K12		PIK3CD, PRKAA2
11	miR-101a	DUSP1, NLK, TGFBR1, CACNB2, FGF10	TGFBR1, SMAD3	HIF1A, PRKAA1
12	miR-103	PRKCA, CDC25B	BMP2	CAB39L, PGF
13	miR-125a	TRAF6, MAP3K11	INHBE
14	miR-133a	ARRB1, B230120H23RIK, FGF12, MECOM	PPP2CA, PPP2CB
15	miR-148b	SOS2, IKBKB, GADD45A	INHBB, NOG, ACVR1	ULK3, RICTOR, MLST8
16	miR-199	MAP3K4, ACVR1C	ACVR2A, RBL1, ACVR1C	MTOR
17	miR-378a	CACNG8, RASGRF1, ELK4,; PLA2G12A, TRAF6
18	miR-425a	MEF2C, DUSP2, MAP2K1, TGFBR2, IL1A	TGFBR2, FST	IGF1, CAB39, FIGF
19	miR-582	BDNF, PPM1B, RASA2, TGFB2	SMAD1, TGFB2
20	miR-3068	RASGRP3, MAPT, FGF12,; CACNA1C, IL1A	PPP2CB, ID4, ACVR1	PIK3CA