Research Article
Experimental Gestational Diabetes Mellitus Induces Blunted Vasoconstriction and Functional Changes in the Rat Aorta
Figure 4
Contractions induced with phenylephrine in isolated intact thoracic aortic rings from pregnant rats fed standard diet, SD (♦), or hypercaloric diet, HD (). Graphs were constructed using the percentage of contraction respect to KCl maximal effect (100%). (a) Vessels without antagonists, (b) pretreated with prazosin (3.1 × 10−9 M) or (c) losartan (1 × 10−7 M). Contractions induced with phenylephrine in isolated thoracic aortic rings endothelium-denuded from pregnant rats fed standard diet, SD (♦), or hypercaloric diet, HD (). (d) Vessels without antagonists, (e) pretreated with prazosin (3.1 × 10−9 M) or (f) losartan (1 × 10−7 M). Dates are the mean ± SEM of 4–7 experiments. versus SD, versus SD, and versus SD.
| (a) |
| (b) Prazosin 3.1 × 10−9 M |
| (c) Losartan 1 × 10−7 M |
| (d) |
| (e) Prazosin 3.1 × 10−9 M |
| (f) Losartan 1 × 10−7 M |