Experimental Gestational Diabetes Mellitus Induces Blunted Vasoconstriction and Functional Changes in the Rat Aorta

Table 2

Angiotensin II (%) and pD2 () of aortic rings from pregnant rats fed SD and HD with and without endothelium.

	Endothelium-intact aortic rings
	SD		HD
	(%)	pD2 ()	(%)	pD2 ()
Ang II	9,658 ± 1,733	6,059 ± 0,3473	2,093 ± 0,4685^&&	7,434 ± 0,8589
Ang II/prazosin	14,84 ± 1,673	6,828 ± 0,2918	2,301 ± 0,5973^&&&	5,517 ± 0,4347^&
Ang II/losartan	8,293 ± 1,279	6,595 ± 0,3825	1,265 ± 0,2893^&&	6,328 ± 0,5651
	Endothelium-denuded aortic rings
	SD		HD
	(%)	pD2 ()	(%)	pD2 ()
Ang II	7,794 ± 0,9906	6,571 ± 0,321	10,44 ± 1,81	7,247 ± 0,5114
Ang II/prazosin	13,88 ± 1,99^*	6,484 ± 0,3324	8,956 ± 1,454	6,829 ± 0,4150
Ang II/losartan	23,02 ± 1,756^***	6,145 ± 0,1467	5,593 ± 0,8142^&&&	5,984 ± 0,2810

Values are mean ± SEM for at least five experiments. ^& < 0.05 versus SD; ^&& < 0.01 versus SD; ^&&& < 0.001 versus SD. ^* < 0.05 versus control. ^*** < 0.001 versus control.