Experimental Gestational Diabetes Mellitus Induces Blunted Vasoconstriction and Functional Changes in the Rat Aorta

Table 3

Phenylephrine (%) and pD2 () of aortic rings from pregnant rats fed SD and HD with and without endothelium.

	Endothelium-intact aortic rings
	SD		HD
	(%)	pD2 ()	(%)	pD2 ()
Phenylephrine	104,6 ± 6,817	5,874 ± 0,1533	60,9 ± 8,037^&&	5,252 ± 0,2627
Phen/Prazosin	102,1 ± 9,075	5,763 ± 0,2074	58,12 ± 6,677^&&	5,204 ± 0,2239
Phen/Losartan	107,2 ± 6,777	5,906 ± 0,1488	59,15 ± 7,547^&&	5,523 ± 0,2896
	Endothelium-denuded aortic rings
	SD		HD
	(%)	pD2 ()	(%)	pD2 ()
Phenylephrine	133,8 ± 3,092	6,265 ± 0,0608	127,9 ± 11,45	5,808 ± 0,2126
Phen/Prazosin	137,4 ± 6,2	6,102 ± 0,1124	102,6 ± 6,131^&&	5,644 ± 0,1385
Phen/Losartan	129,8 ± 3,239	6,269 ± 0,0654	105,9 ± 5,799^&	5,644 ± 0,1268

Values are mean ± SEM for at least five experiments.
^& < 0.05 versus SD; ^&& < 0.01 versus SD.