Anti-Inflammatory Effects of Siegesbeckia orientalis Ethanol Extract in In Vitro and In Vivo Models
Figure 2
Effects of SOE pretreatment on -carrageenan-induced paw edema and mouse survival in LPS-challenge model. (a) The ICR mice tube-fed without (control or IND) or with the indicated dose of SOE (10 or 32 mg/kg BW/day) for 7 days were s.c. injected with -carrageenan into right paw plantar, and the degree of mice paw edema was recorded. The positive control mice were s.c. injected with indomethacin (20 mg/kg BW) at 3 h before -carrageenan challenge. S.I. = the volume of right paw/the volume of left paw. A significant difference from the control was indicated as or by Student’s -test. (b) The BALB/c mice tube-fed without (control or PDTC) or with the indicated dose of SOE (10 or 32 mg/kg BW/day) for 7 days were i.p. injected with LPS, and mouse survival was recorded. The positive control mice were i.p. injected with PDTC (50 mg/kg BW) at 1 h before LPS challenge. The LSOE, HSOE, and PDTC positive control groups had increased survival using the COX proportion hazards regression test (, 0.019, and 0.006, resp.).
