Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 329712, 10 pages
http://dx.doi.org/10.1155/2014/329712
Research Article

Anti-Inflammatory Effects of Siegesbeckia orientalis Ethanol Extract in In Vitro and In Vivo Models

1Department of Nutrition, I-Shou University, Kaohsiung 82445, Taiwan
2Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung 84001, Taiwan
3Department of Obstetrics and Gynecology, E-DA Hospital, I-Shou University, Kaohsiung 82445, Taiwan
4Division of Cardiology, E-DA Hospital, I-Shou University, Kaohsiung 82445, Taiwan
5Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, E-DA Hospital, I-Shou University, Kaohsiung 82445, Taiwan

Received 4 April 2014; Revised 12 July 2014; Accepted 21 July 2014; Published 26 August 2014

Academic Editor: Chia-Chien Hsieh

Copyright © 2014 Yong-Han Hong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Libby, “Inflammation and cardiovascular disease mechanisms,” The American Journal of Clinical Nutrition, vol. 83, no. 2, pp. 456–460, 2006. View at Google Scholar · View at Scopus
  2. S. E. Shoelson, L. Herrero, and A. Naaz, “Obesity, inflammation, and insulin resistance,” Gastroenterology, vol. 132, no. 6, pp. 2169–2180, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. W. Lin and M. Karin, “A cytokine-mediated link between innate immunity, inflammation, and cancer,” Journal of Clinical Investigation, vol. 117, no. 5, pp. 1175–1183, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. U. N. Das, “Critical advances in septicemia and septic shock,” Critical Care, vol. 4, no. 5, pp. 290–296, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Azzolina, A. Bongiovanni, and N. Lampiasi, “Substance P induces TNF-α and IL-6 production through NFκB in peritoneal mast cells,” Biochimica et Biophysica Acta: Molecular Cell Research, vol. 1643, no. 1–3, pp. 75–83, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. J. J. Baldassare, Y. Bi, and C. J. Bellone, “The role of p38 mitogen-activated protein kinase in IL-1β transcription,” Journal of Immunology, vol. 162, no. 9, pp. 5367–5373, 1999. View at Google Scholar · View at Scopus
  7. U. Singh, J. Tabibian, S. K. Venugopal, S. Devaraj, and I. Jialal, “Development of an in vitro screening assay to test the antiinflammatory properties of dietary supplements and pharmacologic agents,” Clinical Chemistry, vol. 51, no. 12, pp. 2252–2256, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Kanoh and B. K. Rubin, “Mechanisms of action and clinical application of macrolides as immunomodulatory medications,” Clinical Microbiology Reviews, vol. 23, no. 3, pp. 590–615, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Bhattacharyya, P. K. Dudeja, and J. K. Tobacman, “Carrageenan-induced NF-κB activation depends on distinct pathways mediated by reactive oxygen species and Hsp27 or by Bcl10,” Biochimica et Biophysica Acta—General Subjects, vol. 1780, no. 7-8, pp. 973–982, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. M. M. Chan, H. Huang, M. R. Fenton, and D. Fong, “In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties,” Biochemical Pharmacology, vol. 55, no. 12, pp. 1955–1962, 1998. View at Publisher · View at Google Scholar · View at Scopus
  11. J. H. O'Keefe, N. M. Gheewala, and J. O. O'Keefe, “Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health,” Journal of the American College of Cardiology, vol. 51, no. 3, pp. 249–255, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Xiong, Y. Ma, and Y. Xu, “Diterpenoids from Siegesbeckia pubescens,” Phytochemistry, vol. 31, no. 3, pp. 917–921, 1992. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Q. Qian, C. Y. Zhang, and H. Z. Fu, “Study on therapeutic mechanism of anti-rheumatism action of herba siegesbeckiae,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 20, no. 3, pp. 192–195, 2000. View at Google Scholar · View at Scopus
  14. W. Hwang, E. Park, C. Jang et al., “Inhibitory effect of immunoglobulin E production by Jin-deuk-chal (Siegesbeckia orientalis),” Immunopharmacology and Immunotoxicology, vol. 23, no. 4, pp. 555–563, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Sun and H. Wang, “Immunosuppressive activity of the ethanol extract of Siegesbeckia orientalis on the immune responses to ovalbumin in mice,” Chemistry and Biodiversity, vol. 3, no. 7, pp. 754–761, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Wang, Y. Zhou, Y. Ye et al., “Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis,” Journal of Ethnopharmacology, vol. 137, no. 3, pp. 1089–1094, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. H. F. Hsu, Z. H. Chen, S. F. Chang et al., “Evaluating the anti-metastatic potential of Anisomeles Indica extract by using human oral squamous carcinoma FaDu cells,” African Journal of Pharmacy and Pharmacology, vol. 6, no. 24, pp. 1782–1791, 2012. View at Google Scholar
  18. National Research Council, “Animal environment, housing and management,” in Guide for the Care and Use of Laboratory Animals, pp. 21–55, National Academy Press, Washington, DC, USA, 1996. View at Google Scholar
  19. Y. H. Hong, W. W. Chao, M. L. Chen, and B. F. Lin, “Ethyl acetate extracts of alfalfa (Medicago sativa L.) sprouts inhibit lipopolysaccharide-induced inflammation in vitro and in vivo,” Journal of Biomedical Science, vol. 16, article 64, no. 1, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. W. Chao, Y. Hong, M. Chen, and B. Lin, “Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-κB trans-activation activity and LPS-induced inflammation,” Journal of Ethnopharmacology, vol. 129, no. 2, pp. 244–249, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Lee, J. Lee, C. Seo et al., “Anti-inflammatory activity of Angelica dahurica ethanolic extract on RAW264.7 cells via upregulation of heme oxygenase-1,” Food and Chemical Toxicology, vol. 49, no. 5, pp. 1047–1055, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. A. K. Clark, E. A. Old, and M. Malcangio, “Neuropathic pain and cytokines: current perspectives,” Journal of Pain Research, vol. 6, pp. 803–814, 2013. View at Google Scholar
  23. D. Laveti, M. Kumar, R. Hemalatha et al., “Anti-inflammatory treatments for chronic diseases: a review,” Inflammation and Allergy-Drug Targets, vol. 12, no. 5, pp. 349–361, 2013. View at Google Scholar
  24. X. Ye, W. Zhou, Y. Li et al., “Darbufelone, a novel anti-infammatory drug, induces growth inhibition of lung cancer cells both in vitro and in vivo,” Cancer Chemotherapy and Pharmacology, vol. 66, no. 2, pp. 277–285, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Jung, U. Seo, J. Kim, K. Leem, and Y. Park, “Flower extract of Panax notoginseng attenuates lipopolysaccharide-induced inflammatory response via blocking of NF-κB signaling pathway in murine macrophages,” Journal of Ethnopharmacology, vol. 122, no. 2, pp. 313–319, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. C. J. Morris, “Carrageenan-induced paw edema in the rat and mouse,” Methods in Molecular Biology, vol. 225, pp. 115–121, 2003. View at Google Scholar · View at Scopus
  27. H. Park, Y. H. Kim, H. W. Chang, and H. P. Kim, “Anti-inflammatory activity of the synthetic C-C biflavonoids,” Journal of Pharmacy and Pharmacology, vol. 58, no. 12, pp. 1661–1667, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Lim, J. Yoon, Y. Kim, M. Lee, S. Park, and H. Choi, “Free radical-scavenging and inhibition of nitric oxide production by four grades of pine mushroom (Tricholoma matsutake Sing.),” Food Chemistry, vol. 103, no. 4, pp. 1337–1342, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. S. J. Wu, J. Y. Fang, C. C. Ng, C. Y. Wang, and Y. T. Shyu, “Anti-inflammatory activity of Lactobacillus-fermented adlay-soymilk in LPS-induced macrophages through suppression of NF-κB pathways,” Food Research International, vol. 52, no. 1, pp. 262–268, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. T. D. Gilmore and M. R. Garbati, “Inhibition of NF-κB signaling as a strategy in disease therapy,” Current Topics in Microbiology and Immunology, vol. 349, pp. 245–263, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. K. M. Ardeshna, A. R. Pizzey, S. Devereux, and A. Khwaja, “The PI3 kinase, p38 SAP kinase, and NF-κb signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells,” Blood, vol. 96, no. 3, pp. 1039–1046, 2000. View at Google Scholar · View at Scopus
  32. K. Hochrainer, G. Racchumi, and J. Anrather, “Site-specific phosphorylation of the p65 protein subunit mediates selective gene expression by differential NF-κB and RNA polymerase II promoter recruitment,” The Journal of Biological Chemistry, vol. 288, no. 1, pp. 285–293, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Guma and G. S. Firestein, “C-Jun N-terminal kinase in inflammation and rheumatic diseases,” Open Rheumatology Journal, vol. 6, no. 2, pp. 220–231, 2012. View at Publisher · View at Google Scholar · View at Scopus