Curcumin Loaded Microsponges for Colon Targeting in Inflammatory Bowel Disease: Fabrication, Optimization, and <i>In Vitro</i> and Pharmacodynamic Evaluation

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Formulation </td><td align="left">Disadvantage</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">Guar-gum based tablet</td><td align="left">Single unit system has disadvantage of unintentional disintegration of tablet in GIT, which may lead to compromised systemic bioavailability. </td></tr><tr><td align="center" colspan="2"><hr/></td></tr><tr><td align="left">Microspheres and nanoparticles</td><td align="left">Microspheres and nanoparticles are comparatively nonporous in nature and have less capability to bind to the rough surface of intestinal mucosa as compared to microsponges particles.</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Disadvantages of various curcumin colon targeted formulations.

BioMed Research International

tab1

Table 1

Table 1: Curcumin Loaded Microsponges for Colon Targeting in Inflammatory Bowel Disease: Fabrication, Optimization, and <i>In Vitro</i> and Pharmacodynamic Evaluation 

Table 1 | Curcumin Loaded Microsponges for Colon Targeting in Inflammatory Bowel Disease: Fabrication, Optimization, and In Vitro and Pharmacodynamic Evaluation 