An Intelligent Clinical Decision Support System for Patient-Specific Predictions to Improve Cervical Intraepithelial Neoplasia Detection

Table 15

Definition of positivity of the medical tests involved in this study for performance evaluation purposes.

Medical tests	Definition of positivity
Pap test (cut-off ASCUS+)	ASCUS or worse
Pap test (cut-off LSIL+)	LSIL or worse
Pap test (cut-off HSIL+)	HSIL or worse
HPV DNA test	Existence of any HPV subtype found by the HPV DNA test
HR-HPV DNA	Existence of at least one of the high-risk subtypes found by the HPV DNA test
NASBA E6/E7 HPV mRNA test	Positive result of the E6/E7 HPV mRNA test (NASBA) for any of the HPV subtypes 16, 18, 31, 33, and 45
Flow cytometric E6/E7 HPV mRNA assay	Positive result of the identification of E6/E7 mRNA expression of high-risk HPV using flow cytometry technique (positive expression >1.5%)
p16	Positive result of the p16 immunocytochemical examination

Different positivity thresholds have been taken into consideration for Pap test and HPV DNA test. HR-HPV: high-risk human papillomavirus, ASCUS: atypical squamous cells of unknown significance, LSIL: low-grade intraepithelial lesion, and HSIL: high-grade squamous intraepithelial lesion.