Epigenetic Control of Autophagy by MicroRNAs in Ovarian Cancer
Table 2
Genes coding for proteins involved in the autophagy pathway identified as targets of microRNA involved in the cytotoxic response to cis-Platinum in ovarian cancer (miRanda release, August 2010; TargetScan release 6.2.).
miRNAs (involved in cis-Pt response)
Predicted gene(s) involved in autophagy
Function
Target prediction
miRanda
TargetScan
hsa-miR-27a
PDK1
Kinase for the phosphorylation of AKT in Thr308
Yes
Yes
TSC1
Tuberose Sclerosis Complex component that negatively regulates mTOR
Yes
Yes
hsa-miR-23a
UVRAG
Interacts with Beclin-1 and Bif-1 (activation and stimulation macroautophagy)
Yes
Yes
ATG12
A ubiquitin-like protein that modifies (autophagosome expansion)
Yes
Yes
BCL2
Interactor of Beclin-1 (represses autophagy) and of Bax (represses apoptosis)
Yes
Yes
PTEN
Protein/lipid phosphatase that reduces the level of PIP3, thus limiting the activation of AKT
Yes
Yes
TSC1
Tuberose Sclerosis Complex component that negatively regulates mTOR
Yes
Yes
RAPTOR
Regulatory associated protein of mTOR (component of MTORC1)
No
Yes
hsa-miR-378
—
hsa-let-7i
ATG4B
Processing of MAP1-LC3
Yes
Yes
ATG16L1
A component of the ATG12-ATG5-ATG16 complex for the formation of autophagosome
Yes
Yes
TSC1
Tuberose Sclerosis Complex component that negatively regulates mTOR
