Epigenetic Control of Autophagy by MicroRNAs in Ovarian Cancer
Table 3
Genes coding for proteins involved in the autophagy pathway identified as targets of the microRNA involved in the epithelial-to-mesenchymal transition process in ovarian cancer (miRanda release, August 2010; TargetScan release 6.2.).
miRNAs (involved in EMT)
Predicted gene(s) involved in autophagy
Function
Target prediction
miRanda
TargetScan
hsa-miR-141 hsa-miR 200a
ATG7
A ubiquitin-activating (E1) enzyme homolog that activates both ATG8/LC3 and ATG12
Yes
Yes
PTEN
Protein/lipid phosphatase that reduces the level of PIP3, thus limiting the activation of AKT
Yes
Yes
TSC1
Tuberose Sclerosis Complex component that negatively regulates mTOR
Yes
Yes
hsa-miR 29c
ATG14L
A component of the class III PtdIns 3-kinase complex
No
Yes
PTEN
Protein/lipid phosphatase that reduces the level of PIP3, thus limiting the activation of AKT
Yes
Yes
hsa-miR-101
MTOR
Mammalian target of rapamycin (kinase) component of MTORC1 (that inhibits autophagy) and of MTORC2 (that phosphorylates Akt)
No
Yes
RAB5A
Endocytic vesicle associated ras-homolog GTPase (involved in autophagosome formation)
Yes
Yes
hsa-miR-506
—
hsa-miR-128
PDK1
Kinase that phosphorylates AKT in Thr308
Yes
Yes
TSC1
Tuberose Sclerosis Complex component that negatively regulates mTOR
